Formulation and Evaluation of Orodispersible Tablets of Salbutamol Sulphate

Objective of the present work is to develop orodispersible tablets of Salbutamol sulphate to improve bioavailability, disintegration time, dissolution efficacy and patient compliance. Orodispersible tablets are the fast growing and highly accepted drug delivery system in now days mainly to improve patient compliance. Orodispersible tablets have number of advantages over conventional dosage forms, because of that Orodispersible tablets have emerged as an alternative to conventional dosage forms. Orodispersible tablets dissolve or disintegrates instantly on the patient tongue or buccal mucosa. Orodispersible tablets of solbutamol sulphate were prepared using superdisintegrants, ac di sol, sod.cmc, alginic acid, chitosan, mcc, as diluents by direct compression method. Twelve formulations were prepared using the superdisintegrants at lower, intermediate & higher concentration. Mannitol is used to enhance the organoleptic properties of tablets. Tablets were evaluated for uniformity of weight, hardness, friability, water absorption ratio, dispersion time, disintegration time and in vitro drug release. All the formulations showed disintegration time less than 33mins and drug release by dissolution (100% at the end of 10 mins). INTRODUCTION: The tablet is the most widely used dosage form because of its convenience in terms of selfadministration, compactness, and ease in manufacturing. However, geriatric and pediatric patients experience difficulty in swallowing conventional tablets, which leads to poor patient compliance. To overcome this weakness, scientists also have developed innovative drug delivery systems known as melt in mouth or mouth dissolve (MD) tablets. These are novel types of tablets that disintegrate/ dissolve/ disperse in saliva. Their characteristic advantages such as administration without water, anywhere, anytime lead to their suitability to geriatric and pediatric patients. They are also suitable for the mentally ill, the bedridden, and patients who do not have easy access to water. The benefits, in terms of patient compliance, rapid onset of action, increased bioavailability, and good stability make these tablets poplar as a dosage form of choice in the current market. Drinking water plays an important role in the swallowing of oral dosage forms. Often times people experience inconvenience in swallowing conventional dosage forms such as when water is not available. For these reasons tablets that can easily dissolve or disintegrate in the oral cavity have attracted a great deal of attention. Orodispersible tablets are not only indicated for people who have swallowing difficulties, Salbutamol sulphate is a Beta 2 receptor agonist widely used as bronchodilator to relieve acute as well as chronic attacks of asthma.